【摘要】 目的:探讨柚苷对脑外伤的防治价值及可能机制。方法:将48只大鼠平均分为甲、乙2组,分别用于生物化学检验和神经行为学观察。将甲、乙组大鼠分别随机平均分为4个小组,每组各6只。A组(对照组),除不进行打击外,其余操作同模型组;B组(模型组),自由落体打击法制作脑外伤大鼠模型;C组(柚苷干预组),造模后给予柚苷(50 mg/kg)治疗7 d;D组(柚苷防治组),造模前、后各7 d均给予柚苷。造模前、后分别对乙组大鼠进行神经行为学评分;对甲组大鼠测量其脑皮层和血清中超氧化物歧化酶和丙二醛的含量。结果:与A组比较,B组大鼠损伤脑组织和血液中丙二醛含量增高,超氧化物歧化酶活性降低;与B组比较,C,D组大鼠损伤脑组织和血液中丙二醛含量降低,超氧化物歧化酶活性增高,以D组变化更显著。与A组比较,B组成模后神经行为学评分较高;与B组比较,C,D组神经行为学评分降低;与C组比较,D组作用更明显,神经行为学评分低。结论:柚苷干预有利于减轻大鼠脑外伤后的神经病理损害,促进功能恢复。柚苷的保护作用可能与缓解脑外伤后的氧化应激有关。更多还原

【Abstract】 Objective To study the value of naringin to traumatic brain injury in rats and its possible mechanism.Methods Forty-eight rats were divided into two groups,which received neurological scoring and biochemical test respectively.The rats in each group were randomly divided into four subgroups,six each.Group A was sham-operated control.Group B received traumatic brain injury.Group C was treated with naringin for 7 days after traumatic brain injury.Group D was given naringin continually for 7 days either pro-or post-traumatic brain injury.Traumatic brain injury was induced by weight drop technique and naringin was given orally 50 mg/kg per day.Neurological score,superoxide dismutase and malondialdehyde in serum and damaged brain cortex were detected by small lesion scoring and biochemical methods respectively.Results Compared with group A,superoxide dismutase was elevated,and malondialdehyde was reduced in group B.However,they were retrieved by naringin treatment,especially in group D.Compared with group A,group B showed more obvious sensorimotor dysfunction.Compared with that in group B,neurolodical behavior score was reduced in group C and D.The neurological score was lower in group D than that in group C.Conclusion Naringin treatment can relieve the neuropathological damages and improve the functional recovery.The protective effect is related to the oxidative stress after traumatic brain injury.更多还原