【摘要】 目的:观察国产阿德福韦酯胶囊治疗失代偿期乙肝肝硬化腹水的疗效。方法:对96例乙肝肝硬化伴腹水患者使用阿德福韦酯10 mg,口服,每日1次抗病毒治疗96周,对照组为在同期住院的失代偿期乙肝肝硬化腹水(未应用抗病毒药物)患者92例。并观察两组临床疗效。结果:治疗后有效率及乙型肝炎病毒基因(HBV DNA)转阴率治疗组与对照组比较差异有统计学意义(P<0.01)。且两组均未出现明显不良反应。结论:国产阿德福韦酯(名正)治疗失代偿期乙肝肝硬化伴腹水患者疗效肯定,安全性良好。更多还原

【Abstract】 Objective: To observe the effect of Adefovir dipivoxil on hepatitis B cirrhosis with ascites at decompensation stage.Methods: Ninty-six hepatitis B cirrhosis cases with ascites at decompensation stage were treated with 10 mg Adefovir dipivoxil once a day for 96 weeks.And 92 hepatitis B cirrhosis cases without anti-virus treatment were selected as control.The clinic effects of two groups were compared.Results: There was significant differences in efficacy and hepatitis B virus negative rate between two groups(P<0.01).And both groups showed no side effect.Conclusion: With satisfactory safty,Adefovir dipivoxil is more effective on treating hepatitis B cirrhosis cases with ascites at decompensation stage.更多还原