【摘要】 目的:研究脑胶质瘤术后应用选择性颈动脉化疗的临床疗效,探讨药物选择、化疗时机及给药途径等相关问题。方法:对42例临床资料完整的脑胶质瘤进行次全切或大部分切除,术后经选择性颈动脉宁得朗(ACNU)或威猛(VM26)介入化疗。结果:显效10例,占26.2%;有效14例,占33.3%;微效10例,占23.8%;无变化4例,占9.5%;恶化3例,占7.2%;中位生存期接近23个月。结论:脑恶性胶质瘤术后辅以颈动脉灌注治疗,能抑制肿瘤生长,延长生命;具有疗效好,不良反应小等诸多优点。更多还原

【Abstract】 Objective:To evaluate the effectiveness of selective trans carotid artery chemotherapy after surgery for gliomas,and discuss the selection of drugs,optional time and administration routes.Methods:A total of 42 patients with gliomas that underwent partial or subtotal resection of gliomas were given nimustine hydrochloride(ACNU)or Vumon(VM26)by selective trans carotid artery chemotherapy.Results:Obvious effect occurred in 10 cases(26.2%),effect in 14 cases(33.3%),slight effect in 10 cases(23.8%),no effect in 4 cases(9.5%),and deterioration in 3 cases(7.2%),the mean survival time was about 23 months.Conclusion:Trans carotid artery chemotherapy is effective in inhibiting growth of gliomas and prolonging survival period with little side effect.更多还原