【摘要】 目的:美沙拉嗪和糖皮质激素是治疗溃疡性结肠炎的常用药物,本文的目的是通过研究单独使用美沙拉嗪或联合糖皮质激素治疗溃疡性结肠炎的临床对照研究。方法:通过研究2003～2008年郑州大学第二附属医院的68例溃疡性结肠炎轻度-中度患者,随机分为两组。每组患者为34例,平均年龄分别为47.10,44.12岁。其中一组患者单独使用美沙拉嗪3 g/d,Tid,4 w;另一组患者使用美沙拉嗪3 g/d,Tid和糖皮质激素(氢化考的松200 mg,i.v.gtt 3～7 d后,改为口服的泼尼松30 mg/d),4 w。治疗前后通过Trueloveand Witts病理诊断和分级参照标准进行临床治疗评估。结果:68名患者用药4 w后,单独使用美沙拉嗪的34例患者有70.58%得到了完全缓解;另外使用美沙拉嗪和糖皮质激素的34例患者有88.23%完全缓解。通过临床试验发现美沙拉嗪联合糖皮质激素组缓解率明显高于单独使用美沙拉嗪组(P<0.05);并且明显减少了脓血便次数(P<0.05)。结论:通过美沙拉嗪和糖皮质激素联合应用更有效的提高溃疡性结肠炎活动期缓解率,减少临床症状。更多还原

【Abstract】 Objective:Mesalazine and steroid are useful in the maintenance treatment of ulcerative colitis(UC).The aim of this study was to assess and to compare the efficacy of mesalazine alone and in combination with steroid in the treatment of UC patients.Methods:A retrospective study of 68 patients admitted between March 2003 and December 2008 was done with a mild to moderate clinical flare-up of UC verified with colonoscopy.All patients were divided into two groups based on treatment received.One group including 34(mean age 47.10 years) patients treated with mesalazine alone 1 gm three times a day for 4 weeks during maintenance treatment and another group including 34(mean age 44.12 years) patients treated with combination therapy of mesalazine and steroid.Before and after treatment,Truelove and Witts index was calculated to access the clinical response.Results:Of the 68 patients who completed the study,70.58% of mesalazine alone and 88.23% of combination treatment attained clinical remission.Mesalazine with steroid patients experienced more symptoms free period than mesalazine alone during four weeks treatment(P<0.05).Those patients treated with mesalazine with steroid result in less blood and mucus on their stools(P<0.05).Conclusion:Combination therapy is more effective in the treatment of mild to moderately active UC,with significantly improving clinical response than mesalazine alone.更多还原