【摘要】 氨茶碱与1,2-萘醌-4-磺酸钠和十四烷基二甲基苄基氯化铵在pH=13.0的缓冲溶液中反应生成组成比为1∶2∶2红褐色产物(λmax=455nm),表观摩尔吸光系数ε=4.97×103L·mol-1.cm-1.氨茶碱的浓度在0.73～55μg·mL-1范围内与吸光度(A)呈现良好线性关系,线性回归方程为A=0.25841+0.0497C(×10-5mol.L-1),相关系数r=0.9956.回收率在96.5%以上.该方法用于测定注射液中氨茶碱的含量,结果满意.更多还原

【Abstract】 A rapid,simple and sensitive method for the determination of aminophylline (Amin) using sodium 1,2-naphthoquine-4-sulfonate (NQS) and tetradecyl benzyl dimethyl ammonium chloride (Zeph) is established in this paper. The method is based on the russety product formed from Amin,NQS and Zeph in a buffer solution of pH 13.00,and the stoichiometric ratio of the product is 1∶2∶2. Beer’s law is obeyed in a range of 0.73-55 μg·mL-1 of Amin at the maximum absorption of 455 nm (ε=4.97×103 L·mol-1cm-1).The linear regression equation of the calibration graph is A=0.258 41+0.049 7C,with a linear regression correlation coefficient of 0.995 6. The detection limit is 0.7 μg·mL-1,R.S.D. 1.1% and average recovery rateis in range of 96.5%-103%.This method has been successfully applied to the determination of Amin in pharmaceutical samples.更多还原