【摘要】 目的探讨西酞普兰与氟西汀治疗脑卒中后抑郁的临床疗效及安全性。方法将68例脑卒中后抑郁患者随机分为2组各34例,2组均给予神经内科常规及康复治疗,在此基础上治疗组口服西酞普兰,对照组口服氟西汀治疗。均观察8周。于治疗前及治疗后第2、4、6、8周末采用汉密顿抑郁量表(HAMD)及副反应量表(TESS)评定临床疗效和不良反应。结果治疗8周末,治疗组总有效率为94.1%,对照组为76.5%,2组疗效比较有显著性差异(P<0.05)。2组治疗后HAMD评分均较治疗前有显著下降(P<0.01),随着治疗时间的延续均呈持续性下降。同期2组间HAMD评分比较均无显著性差异(P>0.05)。2组不良反应均较轻微。结论西酞普兰治疗脑卒中后抑郁疗效好,不良反应少,安全性高,依从性好。更多还原

【Abstract】 Objective To explore the efficacy and safety of citalopram and fluoxetine in the treatment of poststroke depression.Methods Sixty-eight poststroke depression patients were randomly divided into two groups,34 cases of each group,both groups received neuromedical routine treatment,rehabilitation,and so on;In addition,research group took orally citalopram and control group did fluoxetine for 8 weeks.Clinical efficacy was assessed with the Hamilton depression scale(HAMD) and adverse reactions with the treatment emergent symptom scale(TESS) before treatment and at the end of the 2nd,4th,6th and 8th week treatment.Results At the end of the 8th week,total effective rates were 94.1% in the research and 76.5% in the control group,respectively,there was significant difference between two groups(P<0.05).After treatment the HAMD scores of both groups lowered more significantly compared with pretreatment(P<0.01) and did continuously along with treatment lasting.There were no significant differences in synchronization group comparisons(P>0.05).Reactions of both groups were mild.Conclusion Citalopram has better effect,milder adverse reactions,higher safety and better compliance in poststroke depression.更多还原