【摘要】 目的评价咪达唑仑对神经外科病人颅内压的影响。方法13例颅内胶质瘤成年病人ASAⅠ~Ⅱ级,择期行开颅手术。在麻醉诱导时,静注咪达唑仑2 mg/kg。分别于注药前、后1、2、3、5、7、10、15和20 min,观察收缩压(SP),舒张压(DP),平均动脉压(MAP),心率(HR),脑灌注压(CPP),颅内压(ICP)的变化。颅内压监测采用腰蛛网膜下腔置管直接测压。结果静注咪达唑仑后SP,MAP,CPP显著降低(15.18±2.21)kPa降至(13.44±1.56)kPa,(11.33±2.14)kPa降至(9.54±1.70)kPa,(9.05±2.46)kPa降至(7.97±2.14)kPa。但随时间延长20 min内恢复至基础水平,DP、HR给药前后无明显变化,ICP给药后明显下降且在观察期内无回升趋势。结论咪达唑仑能降低病人的颅内压,适用于神经外科麻醉,对颅内压增高病人应适当调整用量。更多还原

【Abstract】 Objective To evaluate the intracranial pressure(ICP)changes of neurosurgery patient after intravenous medazolam injection.Methods ICP was measured by directly subarachnoid space tube inserted.After medazolam 2 mg/kg intravenous injection,systolic pressure(SP),diastolic pressure(DP),mean arterial pressure(MAP),cerebral perfusion pressure(CPP)and ICP were determined 1,2,3,5,7,10,15 and 20 minutes after the injection.Results SP,MAP and CPP were decreased significantly after medazolam injection(from(15.18±2.21)to(13.44+1.56) kPa,(11.33±2.14)to(9.54±1.70) kPa and(9.05±2.46)to(7.97士2.14)kPa,respectively),but they recovered to normal level later.While DP and HR had no significant change.ICP also decreased(from(0.26±1.40)to(1.57+1.22)kPa)and was kept at the low level during whole observation.Conclusion Medazolam can decrease patients’ ICP and may be an efficient anesthetic for neurosurgery.更多还原