【摘要】 目的研究经有效微生物群(EM)净化处理后的污染湖水对大鼠的亚慢性毒性作用。方法以南宁市某公园经EM净化湖水为受试物。将110只清洁级Wistar大鼠随机分为低(125ml/kg)、中(250ml/kg)、高(500ml/kg)剂量EM净化湖水组、湖水对照(250ml/kg)组和自来水对照组,每组22只,雌雄各半。采用加入饮水法进行染毒,连续90d。观察动物的一般表现;测定体重及心、肝、肾等脏器重量,并计算脏器系数;检测血常规指标和血清生化指标;观察组织病理学改变。结果未见大鼠有中毒症状和行为异常。各组大鼠的体重,心、肝、肾、脾、睾丸重量及其脏器系数差异无统计学意义,血常规指标、血清生化指标均在正常值范围内,脏器组织病理学检查未见异常。结论在125～500ml/kg范围内,未发现经EM净化湖水对大鼠有亚慢性毒性作用。更多还原

【Abstract】 Objective To study the sub-chronic toxicity of lake water treated with effect microorganisms(EM).Methods One hundred and ten Wistar rats were randomly divided into five groups,11 males and 11 females in each.Three groups were treated orally with lake water depurated with EM,at the doses of 125,250,500 ml/kg respectively,for 90 consecutive days.The other two groups were treated with the untreated lake water(250 ml/kg) and tap water,respectively.The animal’s behavior,body weight,blood and organ tissue indicators were examined.Results No poisoning signs were observed in all animals,no significant difference was found in body weight,blood routine test indexes,the serum test indexes between all treated groups and control groups,and no significant pathological change in the organ tissues of all treated groups and control groups was seen.Conclusion The lake water depurated with EM at doses of 125 to 500 ml/kg may not induce sub-chronic toxicity in rats.更多还原