【摘要】 目的:探讨小于胎龄儿(SGA)出生后3年追赶生长与胰岛素生长因子-1(IGF-1)和生长激素(GH)的关系。方法:分析50例SGA和45例适于胎龄儿(AGA)组幼儿身高、体重标准差得分,血清IGF-1和GH水平及SGA组生长正常和生长落后血清IGF-1和GH水平。结果:AGA和SGA组身高的标准差得分和体重标准差得分差异有统计学意义(P均<0.01);SGA和AGA组,SGA生长正常和生长落后组血清IGF-1和GH水平比较,差异均无统计学意义(P>0.05)。结论:SGA新生儿生后3年体格发育仍落后于同龄正常儿童,但其血清IGF-1和GH水平无明显差异,提示SGA从生后头3年存在IGF-1抵抗,为SGA治疗提供参考数据。更多还原

【Abstract】 Objective:To investigate the small for gestational age (SGA) birth and three years of catch-up growth,and the relationship between insulin-like growth factor-1 (IGF-1) and growth hormone (GH).Method:Choose met the inclusion criteria of the SGA 50 cases as the object of study,appropriate for gestational age (AGA) 45 cases as control group to analyze two sets of children’s physical growth of the relevant information and serum levels of IGF-1 and GH.Result:The control group and SGA group of height standard deviation score and weight standard deviation scores significantly (P <0.01).SGA group and AGA groups serum levels of IGF-1 and GH was no significant difference.3,the growth of normal SGA and growth of backward SGA,serum levels of IGF-1 and GH was no significant difference.Conclusion:Years after birth,SGA children’s growth lagged behind the normal children the same age,but the serum levels of IGF-1 and GH was no significant difference,suggesting that SGA during the first three years of existence from birth IGF-1 resistance,to provide reference data for the SGA treatment.更多还原