【摘要】 目的研究较大样本的国人CYP2D6*10的基因多态性,了解C188T位点上的基因型频率和基因突变频率。方法随机选取门诊体检的健康人491例,检测其CYP2D6*0基因多态性。结果 CYP2D6*10基因野生型纯合子C/C、杂合子C/T、突变型纯合子T/T基因型频率分别为16.7%、43.4%、39.9%。C、T等位基因频率分别为38.4%和61.6%。结论 CYP2D6*10等位基因突变频率在东西方不同人群中有显著不同,在东方人和华人人群中大致相同。更多还原

【Abstract】 Objective This article is to investigate the gene polymorphisms of CYP2D6* 10,especially about the point mutation of C188T in Chinese people.Methods CYP2D6 * 10 gene polymorphisms were detected in 491 Chinese people by PCR-RFLP method.Results The observed frequencies of the C/C,C/T,T/T genotypes were 16.7%,43.4% ,and 39.9% ,respectively.The frequency of C and T allele was 38.4% and 61.6%,respectively.Conclusion There was a significant difference between the western and the oriental in gene mutation frequency,but there were no significant differences in the oriental and Chinese.更多还原