【摘要】 目的分析相应镇静程度下的异丙酚对术后认知功能不同方面的影响,为临床麻醉提供神经心理学依据。方法门诊肠镜检查患者57例行相应镇静程度(BIS)监测下异丙酚靶控输注麻醉,测试患者麻醉前后记忆与学习成绩及常规监测血流动力学参数。结果患者异丙酚麻醉后清醒进行的记忆测试中,瞬间记忆与运算能力(MMSE)中瞬间记忆与即时运算成绩下降(P<0.01)两者之间下降程度无相关性,>40岁年龄组患者测试成绩较<40岁组下降差异明显(P<0.05)。结论异丙酚对患者麻醉后的瞬间记忆、即时运算能力有短暂的影响,年龄越大影响越明显。更多还原

【Abstract】 OBJECTIVE To analyze effects of propofol on cognition in different aspects corresponding to sedation degree after surgery and provide reference gist for neuropsychology in anesthesiology.METHODS Fifty-seven outpatients with ASA physical status Ⅰ or Ⅱ aged 20～65 yrs for intestinal endoscopy were received a propofol target controlled infusional anaesthesia with sedation monitored by BIS.Scores of memory and study or parameter of hemodynamics were tested and recorded before and after anaesthsia.RESULTS Scores of instant memory and immediate arithmetic within MMSE scores were decreased more significantly after awaken from propofol anesthesia than those of before anesthesia(P<0.01)Both of descend degree have no correlation.Testing records were descended significantly with aged above forty years than those of aged under forty years.CONCLUSION Propofol anesthesia might have temporal influence in instant memory,immediate arithmetic.The more older,the more influence obviously.更多还原