【摘要】 目的检测基质金属蛋白酶9(MMP-9)在非小细胞肺癌(Non small cell lung cancer,NSCLC)的表达,探讨其与NSCLC侵袭转移的关系。方法用免疫组化法检测42例NSCLC患者肺癌组织与30例癌旁正常肺组织MMP-9蛋白的表达水平。结果 MMP-9蛋白在肺癌组织的表达高于正常肺组织(P<0.05),MMP-9在有淋巴结转移肺癌组织的表达高于无淋巴结转移肺癌组织的表达(P<0.05),且其表达与NSCLC患者临床分期相关(P<0.05)。MMP-9的表达与NSCLC患者的性别、年龄、组织学类型均无明显相关性(P>0.05)。结论 MMP-9的表达与NSCLC的侵袭转移有关,可成为评价NSCLC恶性程度和预后的辅助指标。更多还原

【Abstract】 Objective To study the expression of matrix metalloproteinase 9 (MMP-9) in non small cell lung cancer (NSCLC). Methods Immunohistochemical technique was used to detect the expression of MMP-9 in 42 cases of NSCLC and 30 cases of normal lung tissue. Results MMP-9 was highly expressed in NSCLC in contrast to its low level of expression in non-neoplastic lung-adjacent tissue (P<0.05). The increased MMP-9 protein expression of the NSCLC tissue was significantly associated with higher lymphnode metastases level (P<0.05) and poor tumor stage (P<0.05),but was not correlated with sex or age of patients,different differentiation of tumour. There was no significant difference in MMP-9 expression between squamous cell carcinoma and adenocarcinoma (P>0.05). Conclusion Over-expression of MMP-9 in lung cancer might play an important role in the invasion and metastasis of the tumor. It can act as a reference index for the malignant level of lung cancer and prognosis.更多还原