Biocompatible and stable core/shell drug nanocarrier with high surface-enhanced Raman scattering activity

【摘要】 <正>A novel drug carrier based on SiO₂-coated silver nanoparticle aggregates and antitumor drug is successfully synthesized.The surface-enhanced Raman scattering（SERS） spectra of the antitumor drug in living cells are obtained.By using silver nano-aggregates as SERS substrates instead of dispersed silver particles, a great improvement of SERS signal intensity is achieved.It is found that the chemical stability of the drug carrier can also be increased with the existence of SiO₂ shell.The adsorbing effect between antitumor drug 9-aminoacridine（9AA） and silver particles is investigated to optimize the SERS signal. The core/shell structure of the drug carrier is characterized by ultraviolet-visible（UV-Vis） spectroscopy and transmission electron microscopy（TEM） pictures.The experimental results show that the drug carrier offers biocompatibility,stability,and high SERS activity,holding the potential for realizing the intracellular drug tracing.更多还原

【Abstract】 A novel drug carrier based on SiO₂-coated silver nanoparticle aggregates and antitumor drug is successfully synthesized.The surface-enhanced Raman scattering（SERS） spectra of the antitumor drug in living cells are obtained.By using silver nano-aggregates as SERS substrates instead of dispersed silver particles, a great improvement of SERS signal intensity is achieved.It is found that the chemical stability of the drug carrier can also be increased with the existence of SiO₂ shell.The adsorbing effect between antitumor drug 9-aminoacridine（9AA） and silver particles is investigated to optimize the SERS signal. The core/shell structure of the drug carrier is characterized by ultraviolet-visible（UV-Vis） spectroscopy and transmission electron microscopy（TEM） pictures.The experimental results show that the drug carrier offers biocompatibility,stability,and high SERS activity,holding the potential for realizing the intracellular drug tracing.更多还原