【摘要】 目的研究奈多罗米钠合成的新方法。方法以3-甲氧基苯胺为原料,经酰化反应、Friedel-Crafts反应、克莱森重排、酯化合环等六步反应得到终产物。结果该合成方法操作简便,条件易控,收率较高。结论该反应路线为一条较为理想的奈多罗米钠合成工艺路线。更多还原

【Abstract】 Objective This study aims at developing a new method to synthesize nedocromil sodium. Methods In this experiment,3-methoxyaniline was taken as the raw material,nedocromil sodium was obtained after a series of chemical reactions including acylation,Friedel-Crafts reaction,Claisen rearrangement,and esterification. Results The six-step synthesis is simple to operate and easy to control conditions,and yield high. Conclusion It is a desirable method for the synthesis of nedocromil sodium.更多还原