【摘要】 近年白色假丝酵母菌感染发病率剧增,随着抗真菌药物的广泛使用,耐药菌株不断出现,耐药现象已经成为药物治疗的严峻挑战。白色假丝酵母菌的耐药机制包括两大类。一是抗真菌药物对真菌细胞作用的下降,其中包括药物靶酶的改变影响了药物与细胞结合和外排蛋白增加使药物外排增加。二是真菌细胞对药物的应激反应,其中包括代谢的改变降低了药物的毒性,细胞在不同压力下伴侣蛋白的活化和信号传导的级联反应。更多还原

【Abstract】 The incidence of candidiasis caused by Candida albicans has increased dramatically in recent years.With the widespread use of antifungal agents,the emergence of medicine resistant strains poses a major challenge to drug treatment.Antimicrobial drug resistance mechanisms can largely be classified into two broad categories.The first category includes mechanisms to bypass the effects of the antimicrobial on the cell.Such mechanisms include alterations in the drug target that block drug binding or increased production of multidrug transporters that simply remove the drug from the cell.The second category includes the stress reaction of the cell to cope with drug.Such mechanisms include metabolic alterations that minimize the toxicity of the drug,as well as the activation of chaperones and signal transduction cascades dedicated to sensing and responding to various stresses.更多还原