【摘要】 子宫内膜异位症是育龄妇女常见病。异位内膜的侵袭性种植是一个多因素参与的复杂过程,涉及多条信号转导通路,其中丝裂原活化蛋白激酶(MAPK)信号通路起了非常重要的作用。异位内膜细胞在局部生长存活并随激素变化发生出血、炎症、免疫等反应。MAPK通路在促异位内膜间质细胞增殖,促炎症因子生成和促血管生成方面均起到显著作用。同时MAPK通路诱导辅助性T(Th)细胞发生Th1/Th2漂移,使异位内膜细胞发生免疫逃逸继而种植生长。更多还原

【Abstract】 Endometriosis is a common disease of women of reproductive age.The invasive implantation of ectopic endometrium is a complicated procedure,which involves in multiple factors and a few signaling pathways and mitogen activated protein kinase(MAPK)signaling pathway plays the important role.Ectopic endometrium implants and grows on the surface of pelvic organs and followed with bleeding,inflammation and immunifaction and the reaction is steroid-dependent.MAPK signaling pathway makes a difference on stimulating endometriotic stromal cell proliferation,stimulating production of inflammatory factor and neovascularization.Also,it makes T helper(Th) cells drift from Th1 to Th2,and makes the ectopic endometrium implant and grow through immune escaping.更多还原