【摘要】 目的了解新生儿分离的金黄色葡萄球菌(金葡菌)临床分布特点及其耐药性,为临床抗感染治疗提供参考。方法回顾性分析湖南省儿童医院2008年1月-2009年12月分离自新生儿的112株金葡菌资料。结果 112株金葡菌主要分离自呼吸道感染者的痰和咽拭子标本(65.18%,73/112),其次为血液、创面分泌物、脓液标本,分别占12.50%、12.50%、7.14%。金葡菌对克林霉素、红霉素、阿莫西林、青霉素耐药率高,达41.08%～96.43%;耐甲氧西林金葡菌(MRSA)20株,占17.86%,对甲氧西林敏感的金葡菌(MSSA)耐药率明显低于MRSA(P=0.00或P<0.05);所有菌株均对万古霉素和利奈唑胺敏感。结论新生儿金葡菌主要分离自呼吸道标本,耐药率较高,新生儿科应加强对金葡菌的监测,合理应用抗菌药物,以延缓耐药菌的产生。更多还原

【Abstract】 Objective To investigate clinical distribution and antimicrobial resistance of Staphylococcus aureus(S. aureus)isolated from neonates,and provide guidance for rational use of antimicrobial agents.Methods One hundred and twelve strains of S.aureus isolated from neonates in Hunan Children’s Hospital between January,2008 and December, 2009 were analysed retrospectively.Results Most strains of S.aureus were isolated from sputum and throat swabs in neonates with respiratory tract infection(65.18%,73/112),the next were from blood,wound secretion and pus,which accounting for 12.50%,12.50% and 7.14% respectively,resistant rate of S.aureus to clindamycin,erythromycin,amoxicillin and penicillin were high(41.08%-96.43%);Methicillin-resistant S.aureus (MRSA)were 20 strains(17.86%),drug-resistance of methieillin-sensitive S.aureus was significantly lower than that of MRSA(P=0.00 or P<0.05);All strains were sensitive to vacomycin and linezolid.Conclusion S. aureus is mainly isolated from respiratory tract specimens,and has strong resistance to antimicrobial agents,monitoring of pediatrics should be strengthened,and antimicrobial agents should be used rationally to prevent the emergence of drug-resistant strains.更多还原