【摘要】 为研制出一种配方简单、性能良好的壳聚糖基伤口敷料,以壳聚糖为主体,采用冷冻干燥法制备了壳聚糖基多孔膜。通过单因素实验,探讨了不同配方和工艺条件下的成膜性、pH、吸水性和透气性能,并采用扫描电镜(SEM)、热重分析(TGA)对膜的结构和性能进行表征。通过实验得到最佳配方和工艺条件:3%的壳聚糖31.5mL,甘油3.5mL,羧甲基纤维素钠0.40g,碳酸氢钠0.1g,剧烈搅拌混匀,预冷冻7h后冷冻干燥。抑菌实验和降解实验表明,该多孔膜对大肠杆菌和金黄色葡萄球菌均有较强的抑菌作用,降解性能良好,是一种理想的伤口敷料。更多还原

【Abstract】 In order to prepare chitosan-based porous membranes of simple formula and good performance, the film was prepared by freeze-drying. To integrate the appearance of membrane, pH, water absorbance and water vapor permeation, we got the proper formula by the research. The structure and properties were characterized by SEM(scanning electron microscopy) and TGA(thermogravimetric analysis). The proper formula and conditions is obtained by research:3% chitosan 31. 5mL, glycerin 3. 5mL, CMC 0. 4g, NaHCO3 0. 1g;mix intensely, and pre-freeze for 7h, then freeze-dry. The result of antibacterial and degredation tests shows: the porous membranes has good performance on antibacterial and degredation property, the film is a kind of ideal wound dressing.更多还原