【摘要】 以聚甲基丙烯酸甲酯为模型材料,利用近两年提出的超临界流体膨胀减压过程,成功制备出了粒径在5μm以下的超细微粒,系统分析了混合器压力和温度、溶液浓度及进液速率对微粒形态、粒径及其分布的影响。结果表明,混合器压力、溶液浓度和进液速率均对微粒粒径及其分布有明显的影响,而混合器温度的影响较小。较理想的操作条件为混合器压力为10MPa、温度为60℃、溶液浓度为10mg/mL、进液速度为3mL/min。更多还原

【Abstract】 The microparticles with diameters less than 5μm were prepared successfully by supercritical fluid expansion depressurization process developed in recent years with poly-methyl methacrylate as model material.The influences of the operation parameters,including the pressure and temperature in the mixing vessel,the solution concentration and the solution feed rate,on the particle morphology,diameter and diameter distribution are investigated in detail.The results show that,the pressure in the mixing vessel,the solution concentration and the solution feed rate have remarkable influence while the temperature in the mixing vessel has little influence on microparticles.The optimal operation condition for preparing poly-methyl methacrylate microparticles in the range of this work is:the pressure of 10MPa and the temperature of 60℃ in the mixing vessel,the solution concentration of 10mg/mL and the solution feed rate of 3mL/min.更多还原