【摘要】 目的观察替米沙坦联合心脑康胶囊治疗糖尿病肾病(DN)的临床疗效。方法选择DN患者60例,随机分成治疗组和对照组,两组均可采用胰岛素和口服降糖药降血糖,对照组使用替米沙坦,治疗组予心脑康胶囊联合替米沙坦,疗程为3个月。治疗前后分别测血压(SBP/DBP)、空腹血糖(FBG)、糖化血红蛋白(HbAlc)、尿素氮(BUN)、血肌酐(SCr)、肾小球滤过率(eGFR)、尿β2微球蛋白(β2-MG)。结果两组SBP、DBP、FBG、SCr、eGFR、尿β2微球蛋白(β2-MG)、HbAlc治疗后与治疗前比较有显著意义(P<0.05);治疗组治疗后BUN、SCr、HbAlc、尿β2微球蛋白(β2-MG)、eGFR与对照组治疗后比较有统计学意义(P<0.05)。结论替米沙坦联合心脑康胶囊治疗DN,在减少尿蛋白、改善肾功能方面明显优于对照组,提示两药合用可有效控制和延缓DN病情的发展。更多还原

【Abstract】 Objective:To observe the therapeutic effect of treating diabetic nephropathy(DN)using Xinnaokang capsule combined with Telmisartan.Methods:60 patients of DN were randomly divided into two groups,treatment group and control group.The control group was given Telmisartan the treating group was given Xinnaokang capsule combined with Telmisartan,the course is 3 months.SBP/DBP、FBG、BUN、SCr、eGFR、urineβ2 tiny globulin(β2-MG)、HbAlc were tested before and after treatment.Results:There was significant difference in SBP、DBP、BUN、SCr、eGFR、urineβ2 tiny globulin(β2-MG)、FPG、HbAlc level before and after treatment in two groups(P<0.05).The data of BUN、SCr、eGFR、urineβ2 tiny globulin(β2-MG)、HbAlc in treatment group was better than the control group.Conclusions:Treating diabetic nephropathy using Xinnaokang capsule combined with Telmisartan has a better effect in reducing the urine protein and improving renal function than control group,hint combination medicine can effectively control and defer the development of the condition of DN.更多还原