【摘要】 在临床应用中,抗肿瘤药物的憎水性将严重影响疗效并造成一系列的副作用,因此,这些憎水性药物的增溶方法一直是研究的热点,其中,两亲嵌段聚合物载药胶束体系是目前最有效的方法之一,该方法通过将憎水性药物包裹在具有"核-壳"结构的纳米微球中以实现增溶目的。本文总结了目前用于载药胶束的两亲嵌段聚合物的材料及胶束的制备方法,介绍了超临界二氧化碳在此类药物胶束制备中的最新应用和该领域目前最为热门的研究方向——对肿瘤细胞具有靶向释药功能胶束的研究进展。更多还原

【Abstract】 The poor water-solubility of the anticancer drugs will cause significant problems during clinical application.A lot of efforts have been paid to solve this problem.Among them,the amphiphilic block copolymeric micelle system is one of the most promising methods.This manuscript will focus on the formation of these polymers as well as the preparation of the polymers and the micelles.The newly developments which include the micelles prepared methods based on supercritical carbon dioxide（ScCO₂） and the tumor targeting drug-loaded micelles are also discussed by this paper.更多还原