【摘要】 采用piston-gap型高压均质机对壳聚糖进行了降解研究,考察了均质压力、循环次数、温度等因素对降解效果的影响,并对降解产物进行了表征。结果表明,当均质压力为130MPa,经循环处理10次的壳聚糖黏均分子量从1465kDa降解至323kDa,其降解效果随均质压力和循环次数的增加而提高,随壳聚糖溶液浓度的增大而降低,而温度和乙酸浓度对其基本无影响。高压均质降解通过机械作用切断壳聚糖分子链,基本不改变产物的结构和脱乙酰度。更多还原

【Abstract】 The degradation of chitosan by piston-gap high pressure homogenizer was studied. The effect of different conditions such as pressure,cycle number,and temperature was investigated and the degradation products were characterized. The results show that the viscosity-average molecular weight of chitosan is effectively decreased from 1465 kDa to 323 kDa at 130 MPa and 10 cycle numbers,and the effect of degradation increases with pressure,cycle number and molecular weight of original chitosan,decreases with concentration of chitosan,while both concentration of acetic acid and temperature have a negligible influence. It was used by mechanical action to scissor the molecular chains in the degradation of chitosan by homogenization and there was no obvious modification of chemical structure of degraded chitosan. The degree of deacetylation (DD) of degradation products was basically the same as the DD of original chitosan.更多还原