【摘要】 目的制备包载卡瓦的脂质体纳米颗粒并研究其稳定性。方法采用旋转薄膜蒸发法制备卡瓦纳米制剂,并对其形貌、大小等进行表征,考察纳米颗粒的稳定性。结果卡瓦脂质体纳米颗粒平均粒径为(99.7±7.6)nm,多分散系数为0.321±0.011,Zeta电位为(-33.9±2.3)mV,包封率为(83.32±0.34)%;纳米溶液于4℃下放置60d,其纳米粒外观、粒径及包封率无明显变化,差异均无统计学意义(P>0.05)。结论卡瓦脂质体纳米颗粒的包封率较高,粒径分布均匀,稳定性良好,为卡瓦的新剂型开发提供了实验依据。更多还原

【Abstract】 Objective To prepare the kava-loaded lipid nanoparticles from Piper methysticum and study their stability.Methods Kava-loaded lipid nanoparticles were prepared by rotary-film evaporation method,and their appearance,size and stability were observed.Results Mean size,polydispersity index,Zeta potential,and entrapment efficiency of kava-loaded lipid nanoparticles were 99.7 nm,0.321,-33.9 mV,and 83.32%,respectively.Their appearance,size and entrapment efficiency showed no obvious changes after storage at 4℃ for 60 days.Conclusion The kava-loaded lipid nanoparticles have high entrapment efficiency,uniform particle size and good stability.The present study provides the experiment evidence for the development of novel dosage form of kava.更多还原