【摘要】 在超声波辐射下,芳香醛、1,3-环己二酮和2-氨基苯并咪唑3组分在离子液体([bmim]Br)介质中经Biginelli反应"一锅煮"合成了一系列新型苯并咪唑并[2,1-b]喹啉-6-酮衍生物.2-氨基苯并咪唑的使用是对经典的Biginelli反应的发展,并且该方法具有反应条件温和、产率较高(65%～86%)及环境友好等优点.产物经IR,1HNMR和元素分析确证了结构.更多还原

【Abstract】 A novel series of benzimidazo[2,1-b]quinazolin-6-ones derivatives was synthesized by a threecomponent Biginelli condensation reaction of aldehydes,2-aminobenzimidazole and 1,3-cyclohexanedione, employing ionic liquid[bmim]Br as a solvent under ultrasound irradiation. The classical Bignelli reaction has been extended by the use of 2-aminobenzimidazole and this method has the advantages of milder reaction conditions,short reaction time( 0. 5 h) ,good yields( 65% —86% ) and environmental benignity. The structures of the products were characterized by IR,1H NMR spectra and elemental analysis.更多还原