【摘要】 设计合成了1-乙酰基-3-(2-羟基-4,6-二甲氧基苯基)-5-苯基-2-吡唑啉(4),测试了其紫外光谱和荧光光谱,研究了其对锌离子的选择性识别作用.结果表明,化合物4作为锌离子荧光探针,受常见离子的干扰较小,对于锌离子有着较高的选择性和较低的检出限.更多还原

【Abstract】 The development of Zn2+ ion chemosensors has received considerable attention. The use of Zn2+ - specific chemosensors in biological systems promises to close the knowledge gap between the well-defined structural biochemistry of zinc and the understanding of zinc homeostasis and action. The synthesis of 1-acetyl-3-( 2-hydroxy-4,6-dimethoxy-phenyl) -5-phenyl-2-pyrazoline( 4) and the studies of it as fluorescent sensors for Zn2 + ion were reported. Its UV-Vis and fluorescence spectrum were detected. The influences of 14 metal ions such as Cu2 + ,Zn2 + ,Co2 + etc. on their fluorescence properties were measured. Spectroscopic studies revealed that the compound 4 had rather strong affinity toward zinc ion. The specificity of the probe 4 toward Zn2 + was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Cu2 + , Co2 + ,Ni2 + ,Na + ,K + ,Ca2 + ,Cr3 + ,Cd2 + ,Al3 + ,Mn2 + ,Pb2 + ,Sr2 + and Sn2 + . However,under identical conditions,fluorescence intensity enhanced significantly in the presence of Zn2 + . So we have developed a new fluorescent sensor( compound 4) . It show high sensitivity and selectivity toward Zn2 + in DMSO aqueous solution.更多还原