【摘要】 建立了同时测定酚氨咖敏片中对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏4组分含量的毛细管气相色谱法。采用SE-30大口径毛细管色谱柱(30 m×0.53 mm,1.0μm),柱温190℃,汽化室温度220℃,检测器为FID,检测温度250℃,载气为高纯N2,分流比为1∶6,内标为盐酸麻黄碱,以无水乙醇为溶剂,样品无需衍生化处理,直接进样测定。样品中各组分完全分离,辅料无干扰,对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏分别在20~2000μg/mL、15~1500μg/mL、10~500μg/mL和20~100μg/mL范围内线性关系良好(r>0.999),各组分的平均回收率在99.6%~101.2%范围内,RSD<2%。更多还原

【Abstract】 A capillary gas chromatographic method for simultaneous analysis of paracetamol, aminopyrine and chlorphenamine maleate four components in tablets was established.After the sample was dissovled in dehydrated alcohol and filtered,the filtrate was analyzed directly on a SE-30 wide bore capillary column(30 m×0.53 mm,1.0 μm) at the column temperature of 190 ℃ and the evaporation chamber temperature of 220 ℃ with a hydrogen flame ionization detector(FID),and the detector temperature was 250 ℃.The carrier gas was nitrogen,and the split ratio was 1∶6.The ephedrine hydrochloride was used as the internal standard.These four components in the sample were separated completely.The good linearities were obtained(r>0.999) over the concentration ranges of paracetamol,aminopyrine,caffeine and chlorpheniramine maleate in 20～2000 μg/mL,15～1500 μg/mL,10～500 μg/mL and 20～100 μg/mL respectively.The average recoveries were 99.6%～101.2% with RSD<2%.This method is suitable for the simultaneous determination of these four constituents in the compound preparations.更多还原