【摘要】 目的:探讨原发性高血压病患者肿瘤坏死因子-α(TNF-α)与胰岛素抵抗(IR)的关联。方法:应用放免法测定41例原发性高血压病患者和38例正常对照组的血清TNF-α及胰岛素(fINS)水平,用胰岛素抵抗指数(HOMA-IR)评价IR程度。结果:高血压组病血清TNF-α水平显著高于正常对照组(P<0.001);HOMA-IR显著高于正常对照组(P<0.001),相关分析显示,在高血压病组及正常对照组中,TNF-α与BMI、HOMA-IR、收缩压(SBP)呈正相关(P<0.05)。结论:高血压病患者血清TNF-α升高,且与肥胖及IR呈正相关。更多还原

【Abstract】 Objective To investigate the relationship between serum tumor necrosis factor-α(TNF-α)levels and insulin resistance(IR)in patients with essential bypertension.Methods Serum TNF-α and free insulin(fINS)levels were measured with RIA in 41 patients with essential hypertension and 38 controls.Insulin resistance was calculated with insulin resistance index(HOMA-IR).Results The serum TNF-α levels were significantly higher in patients with essential hypertension than those in the controls(P<0.001).The HOMA-IR was also significantly higher in hypertension group than that in controls(P<0.001).Serum TNF-α levels was positively correlated with BMI,HOMA-IR and SBP both in hypertension group and control group(P<0.05).Conclusion Serum TNF-α level was increased in hypertensive patients and positively correlated with obesity and IR.更多还原