【摘要】 目的:外周血WBC是否参与了2型糖尿病(DM2)及微血管病变的发生发展。方法:受试者分为正常对照、无并发症DM2、伴微血管病变DM2等3组,检测正常对照组及DM2患者外周血WBC及代谢综合征相关指标,t检验分析组间WBC水平的差异,spearman相关分析DM2患者WBC水平与其他指标的相关性。结果:无并发症及微血管病变并发症DM2 WBC水平显著高于正常对照者,t值分别为3.08、2.94,P<0.05,但无并发症与微血管病变DM2间WBC无显著性差异,t=0.89,P>0.05;相关分析显示,WBC计数与年龄、体重指数(BMI)、三酰甘油(TG)、2h血糖(PBG)、2h胰岛素呈正相关,r值分别为0.248、0.201、0.435、0.225、0.352,P均<0.05。结论:外周血WBC可能参与DM2及微血管病变的发生发展,WBC计数一定程度上可作为预测DM2发生的一个指标。更多还原

【Abstract】 Objective To study the possible role played by peripheral white blood cells in the development of type 2 diabetes(DM2) and complication of microvascular pathological changes.Methods White blood cell count and metabolism related paratmeters(FBG,2hPBG,2h Pinsulin,TCH,HDL,LDL,TG,HbA1c,BMI,age) were examined in 33 DM2 patients without complication,41 DM2 patients with micro-angiopathy and 31 controls.Results The white blood cell counts in both DM2 patients with no complication and the DM2 with microvascular pathological changes were significantly higher than those in controls(P<0.05),but there were no significant differences between the counts in the two groups of patients(P>0.05).The white blood cell counts were positively correlated with age,body metabolism index(BMI),triglyceride(TG),2h glucose(PBG) and 2h insulin(the r value 0.248,0.201,0.435,0.225,0.352 respectively,P<0.05).Conclusion Peripheral white blood cells possibly played some role in development of DM2 and microvascular pathological changes and might be of some predictive importance.更多还原