【摘要】 目的研究阿托伐他汀对无症状性脑梗死二级预防的临床疗效。方法将300例经头颅CT或MRI证实有梗死的无症状性脑梗死病人随机分为治疗组和对照组。治疗组用阿托伐他汀10 mg qn,对照组不用阿托伐他汀,采用其他治疗,如生活方式调整、控制血糖、血压等。进行双盲对照治疗3 a,观察两组病人症状性脑梗死的发生率和不良反应,并作统计学分析。结果治疗组症状性脑梗死3 a发生率(5.3%)明显低于对照组(14.7%),P<0.05。结论阿托伐他汀对无症状性脑梗死二级预防的临床疗效确切。更多还原

【Abstract】 Objective To investigate the clinical effect of atorvastatin on the silent cerebral infarction randomly in the period of three years.Methods 300patients with silent cerebral infarction were diagnosed by cerebral CT or MRI and divide into therapy group and contrast group randomly.The two groups were treated with the same method such as life-style remodeling,control blood pressure and blood glucose,except atorvastatin 10 mg qn in the treatment group.Results 5.3% and 14.7% of the silent cerebral infarction developed into the symptomatic cerebral infarction at the end of three years respectively(P<0.05).Conclusions The study indicates that atorvastatin may play an effective role in the secondary prevention of the silent cerebral infarction.更多还原