【摘要】 目的了解恩施地区慢性乙型肝炎(乙肝)患者HBV DNA YMDD变异的情况。方法检测该地区100例乙肝患者ALT水平、HBV DNA载量、HBV YMDD变异,对其HBV DNA YMDD变异情况进行分析。结果 100例乙肝患者中检出HBV DNA YMDD变异共15例(阳性率15%),已服用拉米夫定者60例,检出YMDD变异12例(阳性率20%),未服用拉米夫定患者40例,检出YMDD变异3例(阳性率7.5%)。15例YMDD变异患者HBV DNA在5.21×104~1.34×108copies/ml,ALT水平在38~1100U/L。结论恩施地区乙肝患者YMDD变异可在拉米夫定治疗过程中出现,也可天然存在;尚未发现恩施地区乙肝患者性别、年龄、HBV DNA载量、ALT水平对YMDD变异检出率有显著影响更多还原

【Abstract】 Objective To investigate the existence of HBV DNA YMDD mutation in patients with chronic hepatitis B in Enshi Autonomous prefecture.Methods The ALT level,HBV DNA,and HBV DNA YMDD mutation in the patients with chronic hepatitis B were detected and analyzed.Results HBV DNA YMDD mutation was found in 15 out of 100 patients with hepatitis B(positive rate 15%).HBV DNA YMDD mutation was found in 12 out of 60 patients receiving lamivuding therapy(positive rate 20%),but HBV DNA YMDD mutation was found in 3 out of 40 patients without lamivuding therapy(positive rate 7.5%).In the 15 patients with HBV DNA YMDD mutation,HBV DNA and ALT level were 5.21×104～1.34×108 copies/ml and 38～1100 U/ L respectively.Conclusion The existence of HBV DNA YMDD mutation in patients with chronic hepatitis B in Enshi Autonomous Prefecture may occur during the process of lamivuding therapy or may exist naturally.The existence of HBV DNA YMDD in patients with chronic hepatitis B mutation in Enshi Autonomous Prefecture is unrelated with gender,age,serum viral load or ALT level.更多还原