【摘要】 【目的】探讨中枢性协调障碍(central coordination disturbance,CCD)患儿的高危因素,为临床诊治提供参考依据。【方法】收集2008年1月—2009年6月收治的308例CCD患儿为CCD组,同时设置健康对照组300例,对两组儿童相关病史资料进行回顾性统计分析。【结果】 1)308例CCD患儿中22例(7.1%)无明显危险因素,余286例(92.9%)各有一种或多种危险因素,共计1 026例次,其中产前母体因素429例次(41.8%);产时异常因素344例次(33.5%);产后新生儿期异常因素253例次(24.7%),平均每例计3.3个危险因素;2)含1种危险因素的儿童两组差异无统计学意义,含2种危险因素的儿童有统计学意义(P<0.05),而含3种或3种以上危险因素的儿童两组差异有高度统计学意义(P<0.001);3)采用条件Logistic回归分析发现剖宫产、病理性黄疸、多次人流、孕早期感冒、早产、糖尿病、后期发热、窒息/缺氧、先兆流产、化脓性脑膜炎及母亲高龄与CCD的发生相关。【结论】多种高危因素均可导致CCD的发生,而产前因素占主体因素。提示切实做好孕期保健,正确处理分娩时的异常情况,积极救治高危新生儿,能有效降低CCD的发生率。更多还原

【Abstract】 【Objective】 To explore the high risk factor of patients with central coordination disturbance(CCD) 【Methods】 A total of 308 children with CCD in our department,from 2008.1 to 2009.6,were serverd as CCD group,meanwhile 300 healthy children as control group.The total data of two groups was retrospectively analysed. 【Results】 1)22 patients of total 308 cases(7.1%) had no obvious high risk factor,the remaining 286 cases(92.9%) had one or several high risk factors.The total number of factors was 1 026,of which related to antenatal element,the element during delivery and the postpartum element was 429(41.8%),344(33.5%) and 253(24.7%) respectively,and every case had 3.3 high risk factors.2)There was no signficant difference in groups with one high risk factor(P<0.01).Groups with two high risk factors had statistic difference(P<0.05),and those with three high risk factors had signficant difference(P<0.001);3)The logistic regression model analysis showed that uterine-incision delivery,pathological jaundice,induced abortion several times,cold in the early pregnant stage,premature,diabetes,fever in the late pregnant stage,asphyxia/hypoxia,threatened abortion、purulent meningitis and eld puerperant were associated with CCD. 【Conclusions】 Several high risk factors could lead to CCD to happen,and antenatal element was the main factor.It suggested that we should make good antenatal care,deal well with abnormal occurrence in delivery and remedy high risk new born infant actively which would cut down the incidence of CCD effectively.更多还原