【摘要】 目的观察脑钠肽(BNP)在心房颤动(房颤)患者导管消融前后的变化,探讨其在预测房颤复发中的价值。方法经导管消融的房颤患者40例作为实验组,窦性心律患者40例作为对照组,收集实验组术前、术后,对照组入院第2天的血清,采用酶联免疫法测定血清脑钠肽(BNP)浓度。结果房颤组血清BNP浓度显著高于窦性心律组,经过导管消融后血清BNP浓度显著下降,差异有统计学意义。房颤患者导管消融成功组与窦性心律组BNP浓度比较差异无统计学意义,但复发组BNP浓度显著高于对照组,差异有统计学意义。结论BNP可能是预测房颤复发的一个有用指标,可反映心功能状态,BNP越高心功能越差,心功能低的患者房颤复发可能性大,但需要增加样本量进一步研究证实。更多还原

【Abstract】 Objective To observe the changes of serum brain natriuretic peptide(BNP) levels of atrial fibrillation patients before and after catheter ablation,and to explore its value in predicting the recurrence of atrial fibrillation.Methods Forty atrial fibrillation patients with catheter ablation were enrolled as experimental group,and forty patients with sinus rhythm were enrolled as control group.The serum of the experimental group and control group were collected and examined for BNP by enzyme-linked immunosorbent assay.Results BNP concentrations in patients with atrial fibrillation were significally higher than that in patients with sinus rhythm,and were decreased after catheter ablation.BNP concentrations in successful catheter ablation group were the same as that in control group,but were significaintly higher in patients with recurrence of atrial fibrillation.Conclusion BNP can be a predicting factor of recurrence of atrilal fibrillation afrer catheter ablation,but the nomal range of BNP still need to incorparate large-scale clinical studies.更多还原