【摘要】 目的评价血清降钙素原(PCT)和C-反应蛋白(CRP)对慢性支气管炎(慢支)急性发作期的诊断价值。方法 56例慢支急性发作期患者作为观察组,58例健康查体者为对照组,比较分析两组血清PCT和CRP结果。结果 (1)观察组血清PCT水平显著高于对照组,两组相比较差异有统计学意义(P<0.05);观察组的PCT检测阳性率为94.6%,高于对照组(15.5%),两组比较均有显著性差异(P<0.05)。(2)观察组血清CRP水平显著高于对照组,两组相比较有显著性差异(P<0.05);观察组的CRP检测阳性率为30.4%,高于对照组(22.4%),但两组比较差异无统计学意义(P>0.05)。(3)PCT检测对慢支急性发作期诊断的灵敏度、特异度、阳性预测值、阴性预测值和诊断符合率均高于CRP。结论 PCT对慢支急性发作期的诊断较CRP敏感,血清PCT水平可以作为慢支急性发作期的特异性监测指标。更多还原

【Abstract】 Objective To evaluate the diagnostic value of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with acute exacerbation of chronic bronchitis. Methods The PCT and CRP levels were detected in 56 patients with acute exacerbation of chronic bronchitis and 58 healthy control subjects. Results The serum PCT level and positivity rate were significantly higher in the case group than in the control group (P<0.05); the serum CRP level was also significantly higher in the case group (P<0.05), but the positivity rate of CRP was similar between the two groups (P>0.05). The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rate of PCT were higher than those of CRP. Conclusion Serum PCT is more sensitive than CRP in the diagnoses of acute exacerbation of chronic bronchitis, and can be used as a specific indicator for monitoring the condition of the patients.更多还原