【摘要】 目的通过观察冠脉支架术后再狭窄患者冠状动脉重塑指数(RI)与血清脂联素、血浆单核细胞趋化因子-1(MCP-1)和内皮功能的相关性,进而探讨其发生机制。方法测定30例冠脉支架术后再狭窄患者和30例无狭窄患者术后6个月的RI,术前、术后3日和术后6个月的血清脂联素、血浆MCP-1和肱动脉血流介导的内皮依赖性舒张功能(FMD)等指标。结果再狭窄组患者术后3日和6个月的血浆MCP-1水平显著高于术前和同期对照组(P<0.05),术后6个月的RI显著低于同期对照组,术后3日和6个月的FMD和血清脂联素显著低于术前和同期对照组(P<0.05);术后6个月的RI与脂联素和FMD呈显著正相关,与MCP-1呈显著负相关。结论冠脉支架术后再狭窄的发生发展是多因素综合作用的结果。更多还原

【Abstract】 Objective To investigate the correlation between vascular remodeling index (RI) and serum adiponectin,plasma monocyte chemoattractant protein-1 (MCP-1),endothelial function and evaluate the mechanism of coronary in-stent restenosis.Methods RI 6 months after percutaneous coronary intervention (PCI),serum adiponectin,plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis.Results Compared with patients without restenosis and those with restenosis before PCI,the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI,serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05).RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1.Conclusion The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.更多还原