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Surface Characterization and in Vitro Blood Compatibility of Poly (Ethylene Terephthalate) Immobilized with Hirudin

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【作者】 李方； 王进； 孙鸿； 黄楠；

【Author】 LI Fang~(1,2), WANG Jin~1, SUN Hong~1, HUANG Nan~1 1 Key Laboratory of Advanced Technologies of Materials (Southwest Jiaotong University), Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China 2 Petroleum Engineering Institute, Southwest Petroleum University, Chengdu 610500, China

【机构】 Key Laboratory of Advanced Technologies of Materials (Southwest Jiaotong University), Ministry of Education, Southwest Jiaotong University； Petroleum Engineering Institute, Southwest Petroleum University；

【摘要】 <正> Poly (ethylene terephthalate)(dacron,PET) films were exposed under argon plasmaglow discharge with different glows and induced polymerization of acrylic acid(AA) in order to introducecarboxylic acid group onto PET (PET-AA) assisted by ultraviolet radiation(UV).HirudinimmobilizedPET (PET-HRD) films were prepared by the grafting of PET-AA,followed by chemicalreaction with hirudin.The surface structure of the treated PET was determined by X-rayphotoelectron spectroscopy (XPS).The wettability,surface free energy,and interface free energyof the films were investigated by contact angle measurement.The blood compatibility of the filmswas assessed by platelet-adhesion test and fibrinogen conformational change measurements to evaluatethe viability of the materials in biomedical engineering.Measurement by scanning electronmicroscopy (SEM) revealed that the amounts of adhered,aggregated and morphologically changedplatelets were reduced on the hirudin-immobilized PET films.Enzyme-linked-immunoassay measurementsthat disclosed fibrinogen conformational changes showed results consistent with theplatelets’ behavior.

【Abstract】 Poly (ethylene terephthalate)(dacron,PET) films were exposed under argon plasma glow discharge with different glows and induced polymerization of acrylic acid(AA) in order to introduce carboxylic acid group onto PET (PET-AA) assisted by ultraviolet radiation(UV).Hirudinimmobilized PET (PET-HRD) films were prepared by the grafting of PET-AA,followed by chemical reaction with hirudin.The surface structure of the treated PET was determined by X-ray photoelectron spectroscopy (XPS).The wettability,surface free energy,and interface free energy of the films were investigated by contact angle measurement.The blood compatibility of the films was assessed by platelet-adhesion test and fibrinogen conformational change measurements to evaluate the viability of the materials in biomedical engineering.Measurement by scanning electron microscopy (SEM) revealed that the amounts of adhered,aggregated and morphologically changed platelets were reduced on the hirudin-immobilized PET films.Enzyme-linked-immunoassay measurements that disclosed fibrinogen conformational changes showed results consistent with the platelets’ behavior.

【关键词】 hirudin； blood compatibility； poly (ethylene terephthalate)； interface energy； surface energy；
【Key words】 hirudin； blood compatibility； poly (ethylene terephthalate)； interface energy； surface energy；
  • 【文献出处】 Plasma Science and Technology ,等离子体科学和技术(英文版) , 编辑部邮箱 ,2010年02期
  • 【分类号】O631.3
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