【摘要】 目的探讨血清Th17细胞相关因子IL-17在肝囊型包虫病患者中的表达及其临床意义。方法将56例受试者分为3组,健康志愿者(healthy donor,HD)组20例、肝囊型包虫病(cystic echinococcosis,CE)组21例和肝囊型包虫病复发(recurrent cystic echinococcosis,RCE)组15例;应用酶联免疫吸附法(ELISA)检测各组受试者Th17细胞相关细胞因子IL-17的表达。对数据进行t检验。结果血清IL-17水平在CE组(13.4±3.5)ρg/mL和RCE组(13.2±4.7)ρg/mL比对照组HD组(16.4±4.8)ρg/mL降低(t=2.27,t=2.20,P<0.05);RCE组与CE组之间差异无统计学意义(t=0.143,P>0.05)。结论血清IL-17在肝囊型包虫病患者中显著降低,可能与细粒棘球蚴感染过程中免疫调节有关。更多还原

【Abstract】 Objective To investigate the expression of Th17 related cytokine IL-17 in patients with cystic echinococcosis and its significance in immune modulation.Methods Fifty-six subjects were enrolled and divided into 3 groups,healthy donor(HD,n=20),liver cystic echinococcosis(CE,n=21),recurrent cystic echinococcosis(RCE,n=15).The serum concentrations of IL-17 were measured by enzyme-linked immunosorbent assay.Results Serum IL-17 reduced in CE(13.4±3.5) ρg/mL and RCE(13.2±4.7) ρg/mL compared with HD group(16.4±4.8) ρg/mL(t=2.27,t=2.20,P<0.05).However there was no statistical significance between CE and RCE(t=0.143,P>0.05).Conclusions Decreased IL-17in patients with cystic echinococcosis may have correlation with immune modulation during infection progress of echinococcosis.更多还原