原发性肝细胞癌生物学行为与HBV感染及survivin表达的关系

【摘要】 目的探讨在原发性肝细胞癌(hepatocellular carcinoma,HCC)中乙型肝炎病毒(hepatitisBvirus,HBV)感染及survivin蛋白表达对肿瘤生物学行为的影响。方法利用血清学指标检测61例HCC的HBV感染情况,采用辣根酶标记生物素链霉卵白素(SP)检测癌组织中survivin蛋白的表达。结果 39例HBV感染HCC中survivin蛋白表达率为69.23%(27/39),22例非HBV感染表达率为31.81%(8/22),有显著性差异(P<0.05)。在HCC中,HBV感染与肿瘤的Edmondson分级、AFP增高、门静脉癌栓形成、肝内转移及转氨酶升高相关(P<0.05),survivin表达与门脉癌栓形成、肿瘤直经大小及AFP增高相关,与分化程度及肝内转移无关。结论 HBV感染可能与survivin共同作用导致HCC的发生及发展。更多还原

【Abstract】 Objective To study the influences of HBV infection and expression of survivin protein on biological behavious of hepatocellular cancinoma(HCC).Methods The state of HBV infection were determined by serum testsfor 61 patients with hepatocellular cancinoma.Meanwhile,the expression of survivin protein in hepatocellular carcinoma tissues were detected by streptavidin-perosidase(S-P) method.Results The expression rate of survivin was(69.23%(27/39)) of 39 cases with hepatocellular cancinoma infected by HBV was significantly higher than that(31.81%(7/22))of 22 cases not infected by HBV(P<0.05).Among the patients with HCC,the statas of HBV infection is positively correlations with Edmondson gardes,the elevation of serum α-fectoprotien(AFP)levels,intraportal carcinoma embolism,intrahepatic metastasis,and elevation of serum γ-glutamyl transferase(P<0.05).survivin was positively correlations with intraportal embolism,the toumer size and the elevation of serum a-fectoprotien(AFP)levels,have no correlations with differentiation and intrahepatic metastasis,Conclusion The state of HBV infection may join survivin protein in the occurrence and development of HCC.更多还原