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活血化瘀类方乙醇洗脱部位对兔血小板聚集的影响

Effect of alcohol elution component from analogous compound prescription of removing stasis on platelet aggregation on platelet aggregation

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【作者】 王爱云陆茵陈文星段金廒张丽娟孙志广

【Author】 WANG Ai-yun,LU Yin,CHEN Wen-xing,DUAN Jin-ao,ZHANG Li-juan,SUN Zhi-guang(Jiangsu Key Laboratory for TCM Formulae Research,Pharmaceutical College,Nanjing University of Chinese Medicine,Nanjing 210029,China)

【机构】 南京中医药大学药学院江苏省方剂重点实验室

【摘要】 目的:考察活血化瘀类方乙醇洗脱部位对血小板聚集的影响。方法:采用新西兰白兔血浆进行活血化瘀类方乙醇洗脱部位对血小板聚集影响的检测,同时对此类方中的不同成分进行血小板抑制率检测。结果:活血化瘀类方的乙醇洗脱部位中,对血小板聚集有抑制作用的部位集中在10%-50%乙醇洗脱部位。60%-95%乙醇洗脱部位对血小板聚集均没有显著影响。每张方都有抑制血小板聚集的成分存在。结论:活血化瘀类方各组分在不同乙醇洗脱部位含量各有不同,导致各组分在不同乙醇洗脱部位的比例不同,表现出的药理效应也不同。

【Abstract】 Objective:To observe the effect of alcohol elution component from analogous compound prescription of removing stasis on platelet aggregation.Methods:The plasma of New Zealand white rabbits was used to detect the effect of the alcohol elution component on platelet aggregation.At the same time,the effect of different components on platelet aggregation was detected.Results:The alcohol elution component of the decoctions had no effect on platelet aggregation.But every decoction had the components which can inhibit platelet aggregation.Conclusion:The components of analogous compound prescription for removing stasis had different levels.It led to different component proportion ratio.The alcohol elution components of analogous decoctions showed different pharmacologic effect.

【基金】 江苏省高校自然科学重大基础研究项目(No.06KJA36022);江苏省六大人才高峰课题(No.06-B-023,08-A-012);国家自然科学基金项目(No.30772766);江苏省自然科学基金项目(No.BK2007239)~~
  • 【文献出处】 中华中医药杂志 ,China Journal of Traditional Chinese Medicine and Pharmacy , 编辑部邮箱 ,2010年10期
  • 【分类号】R285.5
  • 【被引频次】6
  • 【下载频次】216
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