【摘要】 目的探讨己酮可可碱在胆管阻塞性大鼠肝纤维化模型中的抗纤维化作用。方法雄性SD大鼠60只,分为假手术组、肝纤维化模型组、己酮可可碱组。比较各组肝组织羟脯氨酸含量和组织学评分。结果己酮可可碱组组织评分为2.38分,较模型组(3.5分)显著下降(P﹤0.05)。羟脯氨酸含量模型组[(108.33±14.54)μg/ml]较假手术组[(15.58±4.25)μg/ml]显著升高(P﹤0.05),己酮可可碱组为[(67.50±12.48)μg/ml],与模型组比较下降38%。结论己酮可可碱在大鼠胆管阻塞性肝纤维化模型中具有一定的抗纤维化作用。更多还原

【Abstract】 Objective To study the antifibrotic effect of pentoxifylline (PTX) on rat fibrosis induced by bile duct occlusion. Methods Sixty male SD rats were divided into three groups: sham-operation group, pathologic model group and PTX group[16mg/(kg·d)]. After 6 weeks of treatment,liver histopathological changes, hydroxyproline(Hyp) content were determined. Results Compared with model group,6 weeks of PTX treatment could reduce the histological scoring and Hyp content. Conclusions In rat fibrosis induced by bile duct occlusion,PTX can attenuate hepatic fibrosis.更多还原