【摘要】 探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)升高对心脑血管硬化形成的影响和心脑血管事件危险的相关性。应用化学发光法和免疫比浊法对62名健康体检者和115例急性冠脉综合征(ACS)、脑卒中(ST)、脑梗死(CI)患者住院时血清Hcy和hs-CRP水平进行测定。结果表明ACS、ST、CI三组患者血清Hcy和hs-CRP水平与对照组相比具有显著性差异(P<0.01);且此两项指标升高和心脑血管事件呈正相关(P<0.01)。血清Hcy和hs-CRP升高是心脑血管事件的危险因素且与它们发生发展密切相关。作为常规检测,血清Hcy和hs-CRP联合测定对心脑血管事件的预测、治疗和预防具有重要的临床价值。更多还原

【Abstract】 To investigate the effects of the elevated serum levels of homocysteine(Hcy),hypersensitive C-reaction protein(hs-CRP) on the formation of vascular sclerosis and the risk correlation between cardiocerebral vascular events and these two markers,the serum levels of Hcy and hs-CRP in 115 patients with acute coronary syndrome(ACS),stroke(ST) and cerebral infarction(CI),and 62 healthy controls were detected by chemiluminescence and immunoturdimetry.The results showed that the serum levels of Hcy and hs-CRP in the three-group patients with ACS,ST and CI were significantly higher than those of the control group(P<0.01).There was a positive correlation between the elevated two markers and cardiacerebral events(P<0.05).The elevated levels of Hcy and hs-CRP in serum are risky factors of cardiocerebral events and closely related to the genesis and development of them.The combined detection of serum Hcy and hs-CRP levels might have important clinical value in the prediction,therapy and prevention of cardiocerebral events.更多还原