【摘要】 为探讨高血压对急性心肌梗死(AMI)患者血清白介素-1β(IL-1β)、白介素-6(IL-6)及白介素-8(IL-8)的影响。AMI患者67例,根据高血压病史分为非高血压组37例,高血压组30例,对照组28名,采用ELISA测定各组患者入院第24h、第14d及对照组的血清IL-1β、IL-6及IL-8水平。结果表明非高血压组患者的炎性因子水平于AMI发病第24h显著高于对照组(P<0.001),发病第14天炎症因子水平与对照组相比无显著性差异,高血压组患者AMI发病第24h、第14d血清炎症因子水平均显著高于非高血压组和对照组(P<0.001)。结果显示,IL-1β、IL-6及IL-8参与了AMI的发病,但高血压对炎性因子的升高起到了关键作用。更多还原

【Abstract】 To investigate the influence of hypertension on serum inflammatory markers in patients with acute myocardial infarction(AMI),67 patients with AMI were divided into normotensive group(n=37) and hypertensive group(n=30) and healthy subjects served as control group(n=28).The levels of serum IL-1β,IL-6 and IL-8 at 24 hours,14 days after AMI were determined by ELISA.The results showed that inflammatory markers at 24h after AMI in normotensive group were significantly higher than that in control group(P<0.001).The inflammatory markers in hypertensive group at 24h and 14d after AMI were obviously elevated than that in normotensive group and control group(P<0.001).The results indicate that IL-1β,IL-6 and IL-8 were involved in the course of AMI.Hypertension seems to promote the inflammatory reaction.更多还原