【摘要】 为探讨两组心肌损伤标志物对AMI的早期诊断和预后评估的价值,采用化学发光免疫分析法、免疫比浊法和酶学速率法对79例AMI(急性心肌梗死)组患者和40例非AMI组患者2、4、8、12、24h和2、4、7、14d的血清或血浆进行蛋白肽类标志物(Myo、cTnI、hs-CRP、BNP)和心肌酶学标志物(CK-MB、LDH、AST、α-HBDH)水平的动态测定。结果表明AMI组患者血清或血浆中两组标志物均明显高于非AMI组,具有显著性差异(P<0.01);AMI患者在发病2~4h后联合监测Myo、cTnI、hs-CRP和BNP阳性率明显高于CK-MB、LDH、AST和α-HBDH具有显著性差异(P<0.01)。以上数据表明Myo、cT-nI、hs-CRP和BNP联合测定对AMI作出更准确早期诊断,有较高的临床应用价值。更多还原

【Abstract】 To study the values of detection of two-panel myocardial injury markers in the early diagnosis and prognosis patients with acute myocardial infarction(AMI),the serum or plasma levels of protein-peptidic markers(Myo,cTnI,hs-CRP and BNP) and myoenzymatic markers(CK-MB,LDH,AST and α-HBDH) in 79 patients with AMI and 40 non-AMI patients were measured by Chemiluminescence immunoassay,immunoturbidimetry and enzymatic rate method at 2,4,8,12 and 24 hours and 2,4,7 and 14 days.The results showed that the serum or plasma levels of two-panel injury markers in patients with AMI were significantly higher than those in non-AMI(P<0.01).The positive rates of Myo,cTnI,hs-CRP and BNP in AMI patients were markedly higher than those of CK-MB,LDH,AST and α-HBDH during 2 to 4 hours after AMI(P<0.01).The data indicated that the combined detection of Myo,cTnI,hs-CRP and BNP may be more accurately in the early diagnosis of AMI and have a higher clinical value.更多还原