【摘要】 目的:比较艾司洛尔(esmolol,ESM)和(或)芬太尼对气管插管时循环反应的影响。方法:102例择期手术患者随机分成3组,每组各34例,A组为ESM组,B组为ESM+芬太尼组,C组为芬太尼组。插管前A、B组给予ESM2 mg/kg,B、C组给予芬太尼2μg/kg。静脉注射咪哒唑仑0.1 mg/kg,依托咪酯0.3 mg/kg和维库溴铵0.1 mg/kg诱导插管。记录插管前后收缩压(SBP)、舒张压(DBP)及心率(HR),并计算HR和SBP乘积(RPP)值。结果:插管后1、3、5 min,B组SBP、DBP及RPP降低(P<0.05~P<0.01),A、B两组心率均低于C组(P<0.01)。结论:ESM2 mg/kg可在一定程度下缓解暂时的循环反应,而合用芬太尼2μg/kg能有效抑制插管时的循环反应。更多还原

【Abstract】 Objective:To compare the effect of esmolol(ESM) and/or fentanil on hemodynamic response in tracheal intubation.Methods:One hundred and two adult patients were randomly divided into three groups.Group A and B were administered 2 mg/kg ESM,and group B and C were given 2 μg/kg fentanil before intubation.Tracheal intubation was performed with 0.3 mg/kg etomidate,0.1 mg/kg midazolam and 0.1 mg/kg vecuronium.The SBP,DBP and HR were measured before and after intubation and the RPP was calculated.Results:The SBP,DBP and RPP in group B decreased 1,3 and 5 min after intubation(P<0.05 to P<0.01).The HR in group A and B was lower than that in group C(P<0.01).Conclusions:ESM 2 mg/kg may reduce the hemodynamic response to a certain degree,and ESM 2 mg/kg and fentanil 2 μg/kg can effectively attenuate the hemodynamic response in intubation.更多还原