【摘要】 室温下,先用二甲亚砜(DMSO)将α-溴代酮氧化成1,2-二羰基化合物,不必分离,直接与2,3-二氨基马来腈反应,两步一锅法合成一系列2,3-吡嗪二甲腈衍生物。5-芳基-2,3-吡嗪二甲腈(3a~3f)的产率较高,5-甲基-6-芳基-2,3-吡嗪二甲腈(3g~3i)的产率较低;第二步缩合过程受溶剂的影响较大,使用乙醇做溶剂或不用溶剂产率较好。所有产物的结构都用核磁共振氢谱、核磁共振碳谱、红外光谱和高分辨质谱进行表征。更多还原

【Abstract】 α-bromoketone undergo as dimethyl sulfoxide-mediated oxidation followed by trapping with 2,3-diaminomaleonitrile to give a series of 2,3-pyrazinedicarbonitrile derivatives,in a one-pot procedure at room temperature which avoids the need to isolate the 1,2-dicarbonyl intermediates.All the products are characterized by 1H NMR,13C NMR,IR and HRMS.更多还原