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舒骨康煎剂治疗原发性骨质疏松症60例

Shugukang Decoction in the Treatment of Primary Osteoporosis: A Clinical Observation of 60 Cases

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【作者】 贾经汉陈秀芳张志王向鹏

【Author】 JIA Jing-han1,CHENG Xiu-fang2,ZHANG Zhi1,WANG Xiang-peng1(1.Department of Orthopaedics,Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Guangxi Nanning 530011,China;2.Guilin Hospital of Traditional Chinese Medicine,Guangxi Guilin 541002,China)

【机构】 广西中医学院附属瑞康医院骨科广西壮族自治区桂林市中医院

【摘要】 目的观察中药舒骨康煎剂治疗骨质疏松症的临床疗效,并探讨其作用机制。方法于2005年7月至2008年7月选择90例骨质疏松症门诊患者为研究对象,随机分成舒骨康组(60例)和尼尔雌醇组(30例),两组患者分别口服中药舒骨康煎剂和尼尔雌醇,两组均辅助服用维生素D碳酸钙,连用6个月。治疗前后分别检测两组患者骨矿物质密度(bone mineral density,BMD)、血碱性磷酸酶(alkaline phosphatase,ALP)、血酸性磷酸酶(acid phosphatase,ACP)、血钙(calcium,Ca)、血磷(phosphor,P)及骨钙素(bone glaprotein,BGP)含量。结果舒骨康组和尼尔雌醇组总有效率分别为88.3%、66.7%,两组总有效率比较,差异具有统计学意义(P<0.05);治疗后舒骨康组腰椎BMD显著升高,且显著高于尼尔雌醇组(P<0.05);舒骨康组腰背疼痛和足跟疼痛治愈率显著高于尼尔雌醇组(P<0.05);治疗后舒骨康组BGP和血Ca显著增加(P<0.05),且BGP显著高于尼尔雌醇组(P<0.05),血P、ALP、ACP显著降低(P<0.05);治疗后尼尔雌醇组仅血Ca显著升高(P<0.05)。结论中药舒骨康煎剂与尼尔雌醇治疗老年性骨质疏松症在改善临床症状及减缓BMD下降方面有一定的作用。

【Abstract】 Objective To observe the clinical efficacy of Shugukang Decoction,a traditional Chinese prescription,in treating primary osteoporosis,and explore its mechanism.Methods Ninety outpatients with primary osteoporosis were selected from July 2005 to July 2008 and randomly divided into Shugukang group(n=60) and Nylestriol group(n=30).Based on taking Vitamin D Calcium Carbonate,patients in both groups orally taken Shugukang Decoction and Nylestriol,respectively.The treatment course was 6 months.Before and after treatment,the bone mineral density(BMD),the serum levels of alkaline phosphatase(ALP),acid phosphatase(ACP),calcium(Ca),phosphor(P) and bone gla protein(BGP) in both groups were assayed,respectively.Results The total response rate in Shugukang group was 88.3%, being significantly higher than 66.7% in control group(P<0.05).After treatment,BMD of lumbar vertebra in Shugukang group were significantly increased,being statistically higher than that in Nylestriol group(P<0.05).The recovery rate of lumbodorsal pain and heel pain was significantly higher than that in Nylestriol group(P<0.05).After treatment,BGP and the level of blood Ca in Shugukang group was significantly increased,and BGP being statistically higher than that in Nylestriol group(P<0.05).The serum levels of P,ALP and ACP were significantly decreased(P<0.05).After treatment,only the serum level of Ca in Nylestriol group was significantly increased(P<0.05).Conclusion Shugukang Decoction and Nylestriol have a certain effect in improving the clinical symptoms and delaying the decline of BMD in patients with senile osteoporosis.

【基金】 广西医疗卫生重点科研课题(重200216)
  • 【文献出处】 安徽中医学院学报 ,Journal of Anhui Traditional Chinese Medical College , 编辑部邮箱 ,2010年01期
  • 【分类号】R259
  • 【被引频次】5
  • 【下载频次】118
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