【摘要】 目的分析老年人急性白血病(AL)的临床特点及治疗效果。方法回顾分析43例60岁以上老年AL患者的临床资料,并与同期住院的132例中青年AL患者进行比较。结果老年急性髓细胞白血病(AML):急性淋巴细胞白血病(ALL)为4.38∶1。老年AL患者合并有基础疾病者为86.0%、治疗相关死亡率(33.3%)均高于中青年组(P<0.01);骨髓增生低下发生率(14.0%)、既往骨髓增生异常综合征(MDS)病史率(9.3%)均高于中青年组(P<0.05);完全缓解(CR)率(21.2%)、1年生存率(27.3%)均低于中青年组(P<0.01)。结论老年AL有其临床特点,目前尚无早期诊断治疗的有效策略,应引起重视。更多还原

【Abstract】 Aim To discuss the clinical features and treatment outcome of elderly patients with AL.Methods We reviewed the clinical data of 43 elderly patients with acute leukemia between January 2005 and January 2009,compared with 132 younger adult AL patients in the same period.Results The ratco of elderly AML to ALL is 4.38 to 1.Underlying disease morbidity(86.0%)and rate of treatment related mortality(33.3%)are higher in elderly AL than those in the younger adult AL patients(P<0.01).The rate of low-growth bone marrow(14.0%),MDS history(9.3%)are higher in elderly AL than those in the younger adult AL patients(P<0.01).The CR(21.2%)and one-year survival rate(27.3%)were lower in elderly AL than those in the younger adult AL patients(P<0.01).Conclusion At present,there are not satisfactory strategies to diagnose and treat efficiently elderly AL patients in the early stage,so it should be paid more attentionto.更多还原