【摘要】 目的探讨经皮附睾精子抽吸术(percutaneous epididymal sperm aspiration,PESA)结合卵胞质内单精子显微注射(intracyto-plasmic sperm injection,ICSI)治疗梗阻性无精子症的临床疗效。方法 2005年1月至2008年12月间对42例无精子症患者采用PESA方法进行检测,24例患者附睾液中检出活动精子,其中10例患者采用附睾精子进行了14个周期PESA-ICSI治疗。结果梗阻性无精子症PESA-ICSI组与严重少、弱、畸形精子症或受精障碍者ICSI组的受精率、卵裂率、优质胚胎率、种植率和临床妊娠率分别为82.1%vs79.0%、87.4%vs96.9%、58.7%vs39.0%、16.1vs19.2%和28.6%vs33.3%,经统计学分析,以上指标差异均无统计学意义(P>0.05)。结论 PESA-ICSI方法是治疗梗阻性无精子症的有效方法。更多还原

【Abstract】 Objective To investigate the clinical efficacy of percutaneous epididymal sperm aspiration(PESA) combined with intracytoplasmic sperm injection(ICSI) treatment of obstructive azoospermia.Methods From January 2005 to December 2008,42 patients with azoospermia,PESA method used for detection,24 patients were detected motile sperm from epididymal fluid,of which 10 cases 14 cycles were treated with sperm for PESA-ICSI.Results The obstructive azoospermia PESA-ICSI group compared with less,weak,malformed sperm and fertilized ICSI group impaired fertilization rate,cleavage rate,high quality embryo rate,implantation rate and clinical pregnancy rate were not significantly different(P> 0.05).Conclusion PESA-ICSI is the effective way to treat obstructive azoospermia.更多还原