【摘要】 目的分析安徽省5例人感染高致病性禽流感病例特点,为防治提供科学依据。方法按照《人禽流感流行病学调查方案》,对病例进行个案调查,调查发病经过、治疗情况,实验室检测,可能的感染来源,传播途径及暴露因素等。结果 5例人感染高致病性禽流感初期临床表现主要为流感样症状,4例病例的气管分泌物分离出H5N1禽流感病毒,5例病例的气管分泌物禽流感病毒H5N1核酸均为阳性。1例有明确的病死家禽接触史,死禽也被证实感染禽流感病毒;2例虽有明确的病死家禽接触史,但死禽未被证实感染禽流感病毒;2例病例未发现明确的病死禽接触史;结论 5例病例均为实验室确诊病例;对人禽流感病例的诊断不能完全依据禽流感疫情存在与否;经过对5例人禽流感病例密切接触者的医学观察,没有发现人传人的现象;人禽流感的感染来源、传播途径和影响因素等问题尚待进一步研究。更多还原

【Abstract】 Objective To analyze the features of five Avian-human Influenza cases in Anhui province,and provide a scientific reference for the prevention and control.Methods According to "the epidemiological investigation plan of Avian-human Influenza",case investigation for all cases were conducted,including the process of pathogenesis and treatment,laboratory test,the possible source of infection,the transmission way and the risk factors,etal.Results The initial clinical expression of the five cases was mainly flu-like symptoms,and the Avian Influenza virus H5N1 was detected in the samples of trachea excrete of four cases,and H5N1 virus RNA were positive in 5 trachea excrete samples.One of five cases had definite history of close contact with ill or dead birds,which had infected by Avian influenza virus H5N1 had been confirmed.And 2 of them also had definite history of close contact with ill or dead birds,but there was no evidence that those dead birds had infected by H5N1.The definite history of close contact with ill or dead birds were not found in the other 2 cases.Conclusions Five cases were all pathogen confirmed cases.The diagnosis of Avian-human Influenza case can not rely completely upon whether the epidemic situation existed in the locality or not.The phenomenon that this disease could spread from person to person was not found,through the medical observations of all close contacts of 5 cases.Further researchs are needed needed to understand the possible source of infection,the transmission way and the influential factors.更多还原