【摘要】 目的:通过应用CAG方案(小剂量阿糖胞苷、阿克拉霉素、粒细胞集落刺激因子)治疗老年急性髓系白血病(AML),评价CAG方案治疗老年AML的疗效。方法:应用CAG方案(阿克拉霉素14mg·m-2·d-1,第1~4天静脉滴注;Ara-c10mg·m-2,第1~14天,皮下注射q12h;粒细胞集落刺激因子300ug·d-1,皮下注射,第1~14天。)治疗11例老年AML,一个疗程后评估疗效及不良反应。结果:应用CAG方案治疗的11例老年AML中,3例完全缓解(CR),4例部分缓解(PR),总有效率63.6%,4例未缓解(NR)36.4%。大部分患者出现可耐受的骨髓抑制,未见有明显的心、肝、肾等脏器损害。结论:CAG方案副作用轻微,是治疗老年AML安全有效的诱导方案。更多还原

【Abstract】 Objective: To study therapeutic effect and toxicity of CAG program on elderly patients with acute myeloid leukemia. Methods: The 11 patients were treated with CAG program (a subcutaneous injection of Ara-c 10mg·m-2, every 12 hours, for 1st to 14th days; intravenous drip of Acla 14mg·m-2·d-1, for 1st to 4th days; subcutaneous injection of granulocyte colony-stimulating factor of 300ug·d-1, for 1st to 14th days). Results: CAG program for elderly AML total effective rate was 63.6%, of which 3 cases got complete remission, partial remission 4 cases. Most of the cases had mild marrow inhibition which could be tolerated. No serious heart, liver, kidney and other organ damage. Conclusion: CAG in the treatment of elderly AML has better results and high tolerance of chemotherapy.更多还原