【摘要】 目的:研究信号转导和转录激活因子3(signal transducer and activator of transcription3,STAT3)、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)基因在哈萨克族食管癌中的表达及相关性,从而为探讨哈萨克族食管肿瘤癌变的机制奠定基础。方法:采用RT-PCR方法检测STAT3、VEGF基因在30例哈萨克族食管癌组织及相应癌旁组织(手术切缘无癌组织)中的表达。结果:STAT3、VEGF基因在30例食管癌组织中表达的阳性率分别为73.33%(22/30)和76.67%(23/30),30例癌旁组织中表达的阳性率为43.33%(13/30),两种基因在癌组织中表达的阳性率均高于癌旁组织(P<0.05)。STAT3与VEGF基因的表达具有相关性(P<0.05)。结论:STAT3、VEGF基因的表达可能与哈萨克族食管癌的发生有关,两者之间可能具有协同作用,共同促进食管癌的发生。更多还原

【Abstract】 OBJECTIVE:To study the expressions of STAT3 and VEGF gene and to explore their roles in the process of esophageal cancer in the Kazaks.METHODS:Using RT-PCR to detect STAT3,VEGF in 30 cases of esophageal cancer tissues and their corresponding adjacent tissues.RESULTS:The positive rate of STAT3,VEGF mRNA expressions were 73.33%(22/30)and 76.67%(23/30),respectively,in the esophageal cancers,and 43.33%(13/30)in adjacent tissues.There was significant difference in the expressions of STAT3,VEGF mRNA level between tumor tissue and adjacent tissues.CONCLUSION:STAT3,VEGF gene could have important roles in carcinogenesis of esophageal cancer in the Kazaks.The combined action of STAT3 and VEGF genes could promote carcinogenesis and development of esophageal cancer.更多还原